Klinische Vergleichsstudien Hyaluronsäure

Amer A. et al. (2021): 




Combined autologous platelet-rich plasma with microneedling versus microneedling with non-cross-linked hyaluronic acid in the treatment of atrophic acne scars: Split-face study
Dermatol Ther. 2021 Jan;34(1):e14457  

Mikosinski J. et al. (2021): 




Efficacy and Safety of a Hyaluronic Acid-Containing Gauze Pad in the Treatment of Chronic Venous or Mixed-Origin Leg Ulcers: A Prospective, Multicenter, Randomized Controlled Trial
Wounds Epub 2021 April 7 

Oberreiter M. et al. (2021) : 



The efficacy of hyaluronic acid in combination with an antiseptic - experience from acute military-based wound care
Worldwide Military Medicine ALMANAC 06/2021  PDF-Download

Die Wirksamkeit von Hyaluronsäure in Kombination mit einem Antiseptikum - Erfahrungen aus der akuten, militärischen Wundversorgung
Wehrmedizin und Wehrpharmazie, Wundmanagement 06/2021

Al-Baidhani A. K. S. et al. (2020): 



Advantage of Application of Topical Hyaluronic Acid in Reducing Post Tonsillectomy Pain; Cross Sectional Comparative Study. 
Medico Legal Update, 20(1), 555-559

Çankaya Z.T. et al. (2020): 


Evaluation of the effect o f the application of hyaluronic acid following laser-assisted frenectomy: an examiner-blind, randomized, controlled clinical study. 
Quintessence Int. 2020;51(3):188-201 

Cetinkaya O.A. et al. (2020): 

Treatment of hard-to-heal leg ulcers with hyaluronic acid, sodium alginate and negative pressure wound therapy.
J Wound Care. 2020 Jul 2;29(7):419-423.

De Castro GMP, Muñoz MJR (2020): 


Multicenter Clinical Study to Evaluate the Efficacy and Safety of Hyaluronic Acid and Enzyme Cocktail in Scars.
Dermatología Cosmética, Médica y Quirúrgica 2020; 18 (2) 

Lee M. et al. (2020): 

Clinical Efficacy of Acellular Dermal Matrix Paste in Treating Diabetic Foot Ulcers 
 Wounds. 2020 Jan;32(1):50-56. Epub 2019 Dec 9 

Mandel I. et al. (2020): 

Comparative Evaluation of Two Hyaluronic Acid Gel Products for the Treatment of Interdental Papillary Defects.
Acta Stomatol Croat. 2020 Sep; 54(3): 227–237 

Marin S. et al. (2020): 

Hyaluronic acid treatment outcome on the post-extraction wound healing in patients with poorly controlled type 2 diabetes: A randomized controlled split-mouth study.
Med Oral Patol Oral Cir Bucal. 2020 Feb 10. pii: 23061 

Segreto F. et al. (2020): 

The use of acellular porcine dermis, hyaluronic acid and polynucleotides in the treatment of cutaneous ulcers: Single blind randomised clinical trial
Int Wound J. 2020 Dec;17(6):1702-1708 

De Angelis B. et al. (2019): 

Wound Healing: In Vitro and In Vivo Evaluation of a Bio-Functionalized Scaffold Based on Hyaluronic Acid and Platelet-Rich Plasma in Chronic Ulcers.
J Clin Med. 2019 Sep 18;8(9) 

Kharisma I. et al. (2019): 


The effect of hyaluronic acid on the changes in Matrix Metalloproteinase-1 (MMP-1), leukocytes level, and bacteriocide effects among patients with Wagner 3 and 4 diabetic foot ulcer 
IJBS 2019: 13(2): 57-62 

Lobato J. C. R. F. et al. (2019): 


Single application of 0.8% hyaluronic acid as a coadjuvant of nonsurgical treatment in nonsmoking patients with periodontitis: A split-mouth, randomized, controlled pilot clinical trial. 
J Indian Soc Periodontol. 2019 Nov-Dec; 23(6): 545–548

Mozzanica F. et al (2019): 


Double-blind, randomised controlled trial on the efficacy of saline nasal irrigation with sodium hyaluronate after endoscopic sinus surgery. 
J Laryngol Otol. 2019 Apr;133(4):300-308

Palaia G. et al. (2019): 


Evaluation of wound healing and postoperative pain after oral mucosa laser biopsy with the aid of compound with chlorhexidine and sodium hyaluronate: a randomized double blind clinical trial.
Clin Oral Investig. 2019 Aug;23(8):3141-3151

Riccio M. et al. (2019): 

Managing Pathologic Scars by Injecting Auto-Cross-linked Hyaluronic Acid: A Preliminary Prospective Clinical Study. 
Aesthetic Plast Surg. 2019 Apr;43(2):480-489 

Saputra M. et al. (2019): 

Wound treatment with hyaluronic acid and silver sulfadiazine promote better epithelialization compared to polyurethane and normal saline in diabetic foot ulcer. Ind. J. of Biomedical Science 13(2) 

Tasinato R., Zangrande P.  (2019): 

Topical treatment with a matrix containing mesoglycan in association with hyaluronic acid in the management of chronic skin ulcers of the lower limbs. Our experience in 63 consecutively treated cases. 
June 2019. Italian Journal of Wound Care 3(2)

Youssef M. I. et al. (2019): 


The effect of topically applied hyaluronic acid gel versus topical corticosteroid in the treatment of erosive oral lichen planus. 
Alexandria Dental Journal. (2019) Vol.44 Pages:57-63 

Zourmalan C. et al. (2019): 



Safety and Efficacy of a Scar Cream Consisting of Highly Selective Growth Factors Within a Silicone Cream Matrix: A Double-Blinded, Randomized, Multicenter Study. 
Aesthet Surg J. 2019 Feb 15;39(3):319-330

Afat I.M. et al. (2018): 

Effects of leukocyte- and platelet-rich fibrin alone and combined with hyaluronic acid on pain, edema, and trismus after surgical extraction of impacted mandibular third molars. 
J Oral Maxillofac Surg. 2018 May;76(5):926-932 

Hashem A. S. et al. (2018): 

Topical hyaluronic acid in the management of oral lichen planus: A comparative study   
 Journal of Investigative and Clinical Dentistry. 2019, 10:4, e12385 

Sobotka L. et al. (2018): 

The effect of new self-adherent antimicrobial wound dressing on biofilm in comparison with established silver dressing 
EWMA 2018 Krakow, Poland 9 – 11 May 2018, EP290

Yıldırım S. et al. (2018): 

Effect of topically applied hyaluronic acid on pain and palatal epithelial wound healing: An examiner-masked, randomized, controlled clinical trial.
J Periodontol. 2018 Jan;89(1):36-45. 

Alvarez O.M. et al. (2017): 

Venous Ulcers Treated With a Hyaluronic Acid Extracellular Matrix and Compression Therapy: Interim Analysis of a Randomized Controlled Trial
Wounds 2017;29(7):E51–E54 

Alsaedy S.J. et al. (2017):


The Efficacy of Topical Hyaluronic Acid Serum in Acne Scar Patients Treated with Fractional CO2 Laser
 American Journal of Dermatology and Venereology 2017, 6(2): 17-24 

Capoano R. et al. (2017):


Wounds Difficult to Heal: An Effective Treatment Strategy 
 Curr Vasc Pharmacol. 2017;15(6):582-588

Genovesi A. et al. (2017): 


The efficacy of 0.12% chlorhexidine versus 0.12% chlorhexidine plus hyaluronic acid mouthwash on healing of submerged single implant insertion areas: a short-term randomized controlled clinical trial.
Int J Dent Hyg. 2017 Feb;15(1):65-72 

Loburets, A. et al. (2017): 

The use of drugs with sodium hyaluronate in complex treatment of patients with chronic frontal sinusitis. 
The Medical and Ecological Problems, 21(1-2), 9-13. 

Ozgultekin A. et al. 2017: 



Comparison of hyaluronic acid containing products with wet dressing for severe decubitus ulcers
EP343, EWMA Congress 2017, Amsterdam, The Netherlands, 3–5 May 2017

Scalise A. et al. (2017): 

Enzymatic debridement: is HA- collagenase the right synergy? Randomized double-blind controlled clinical trial in venous leg ulcers
Eur Rev Med Pharmacol Sci. 2017 Mar;21(6):1421-1431 

Amirlak B. et al. (2016): 


A Clinical Evaluation of Efficacy and Safety of Hyaluronan Sponge with Vitamin C Versus Placebo for Scar Reduction.
Plast Reconstr Surg Glob Open. 2016 Jul 11;4(7):e792 

Cassano M. et al. (2016): 

Cytofunctional changes in nasal ciliated cells in patients treated with hyaluronate after nasal surgery.
Am J Rhinol Allergy. Mar-Apr 2016;30(2):83-8 

De Caridi G. et al.  (2016):


Trophic effects of polynucleotides and hyaluronic acid in the healing of venous ulcers of the lower limbs: a clinical study
 Int Wound J. 2016 Oct;13(5):754-8 

Hwang Y. et al. (2016):


Hyaluronic Acid Dressing in the Treatment of Diabetic Foot Ulcer: A Prospective, Randomized, Placebo-Controlled, Single-Center Study 
Foot & Ankle Orthopaedics 2016; 1:1  

Koray M. et al. (2016): 


The Efficacy of Hyaluronic Acid Gel in Pain Control of Recurrent Aphthous Stomatiti Int J Dentistry Oral Sci. 3(6), 273-275 

Lee M. et al.  (2016): 

Hyaluronic acid dressing (Healoderm) in the treatment of diabetic foot ulcer: A prospective, randomized, placebo-controlled, single-center study
Wound Repair Regen. 2016 May;24(3):581-8 

Loburets A. et al.  (2016): 


Approach on rehabilitation of patients after functional endonasal surgery of the frontal sinus.
Wiad Lek. 2016;69(6):714-718. 

Onesti M.G. et al.  (2016): 

Effect of enzymatic debridement with two different collagenases versus mechanical debridement on chronic hard-to-heal wounds.
Int Wound J. 2016 Dec;13(6):1111-1115 

Gocmen G. et al. (2015): 


The antioxidant and anti-inflammatory efficiency of hyaluronic acid after third molar extraction.
J Craniomaxillofac Surg. 2015 Sep;43(7):1033-7 

Hancı D., Altun H. (2015): 


Effectiveness of hyaluronic acid in post-tonsillectomy pain relief and wound healing: a prospective, double-blind, controlled clinical study.
Int J Pediatr Otorhinolaryngol. 2015 Sep;79(9):1388-92  

Ramos-Torrecillas J. et al. (2015): 

Effectiveness of platelet-rich plasma and hyaluronic acid for the treatment and care of pressure ulcers.
Biol Res Nurs. 2015 Mar;17(2):152-8 

Koray M. et al. (2014): 


Efficacy of hyaluronic acid spray on swelling, pain, and trismus after surgical extraction of impacted mandibular third molars. 
Int J Oral Maxillofac Surg. 2014 Nov;43(11):1399-403  

Matheny K.E. et al. (2014): 



Self-cross-linked hyaluronic acid hydrogel in ethmoidectomy: a randomized, controlled trial. 
Am J Rhinol Allergy. Nov-Dec 2014;28(6):508-13 

Romeo U. et al. (2014): 



Oral soft tissue wound healing after laser surgery with or without a pool of amino acids and sodium hyaluronate: a randomized clinical study. 
Photomed Laser Surg. 2014 Jan;32(1):10-6 

Sahayata V.N. et al. (2014):


An evaluation of 0.2% hyaluronic acid gel (Gengigel®) in the treatment of gingivitis: a clinical & microbiological study.
Oral Health Dent Manag. 2014 Sep;13(3):779-85

You H.J. et al. (2014): 

Randomised controlled clinical trial for autologous fibroblast-hyaluronic acid complex in treating diabetic foot ulcers.
J Wound Care. 2014 Nov;23(11):521-2, 524, 526-30 

Cassino R., Ippolito, A. M. (2013): 

Aminoacidic gel versus hydrogel: Which is the quicker debrider?
Acta Vulnol. 2013: 11; 149-159 

Cassino R. et al. (2013): 

A controlled, randomised study on the efficacy of two overlays in the treatment of decubitus ulcers
Minerva Chir. 2013 Feb;68(1):105-16

Eick S. et al. (2013):


Hyaluronic Acid as an adjunct after scaling and root planing: a prospective randomized clinical trial.
J Periodontol. 2013 Jul;84(7):941-9  

Humbert P. et al. (2013): 

Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial
Int Wound J. 2013 Apr;10(2):159-66 

Jain Y. (2013):

Clinical evaluation of 0.2% hyaluronic acid containing gel in the treatment of gingivitis
Med J DY Patil Univ 2013;6:416-20 

Dereure O. et al. (2012): 

Efficacy and safety of hyaluronic acid in treatment of leg ulcers: a double- blind RCT
J Wound Care. 2012 Nov;21(11):539-42, 544, 546-7 

Dereure O. et al. (2012): 

RCT to evaluate a hyaluronic acid containing gauze pad in leg ulcers of venous or mixed aetiology
J Wound Care. 2012 Mar;21(3):131-2, 134-6, 138-9 

Erbatur S. et al. (2012):


Comparision of clinical and histopathological results of hyalomatrix usage in adult patients
Int J Burns Trauma. 2012;2(2):118-25  

Maggio G. et al. (2012):


A new protocol for the treatment of the chronic venous ulcers of the lower limb.
Clin Exp Med. 2012 Mar;12(1):55-60 

Sudarsa I. et al. (2012):


Hyaluronic Acid Caused of Wider Epithelialization Compare to Normal Saline in Severe Diabetic Ulcer
Bali Medical Journal, 2012, 1(1), 32–35 

Brennes R. A. et al. (2011):


Initial experience using a hyaluronate-iodine complex for wound healing 

Am Surg. 2011 Mar;77(3):355-9 

Caravaggi C. et al. (2011):

Wound Bed Preparation With a Dermal Substitute (Hyalomatrix® PA) Facilitates Re-epithelialization and Healing: Results of a Multicenter, Prospective, Observational Study on Complex Chronic Ulcers

Wounds. 2011 Aug;23(8):228-35 

Felzani G. et al. (2011):

Effect of lysine hyaluronate on the healing of decubitus ulcers in rehabilitation patients.

Adv Ther. 2011 May;28(5):439-45 

Uccioli L. et al. (2011): 

Two-step autologous grafting using HYAFF scaffolds in treating difficult diabetic foot ulcers: results of a multicenter, randomized controlled clinical trial with long-term follow-up
Int J Low Extrem Wounds. 2011 Jun;10(2):80-5 

Abbruzzese L. et al. (2009): 

Effectiveness and safety of a novel gel dressing in the management of neuropathic leg ulcers in diabetic patients: a prospective double-blind randomized trial

Int J Low Extrem Wounds. 2009 Sep;8(3):134-40

Nolan A. et al.  (2009):


The efficacy of topical hyaluronic acid in the management of oral lichen planus 

Oral Pathology & Medicine, 2009: 38:3 p. 299-303

Brennes R. A. et al.  (2008): 

Hyaluronate-Iodine Complex (Hyiodine) compared to Papain-Urea in the Treatment of Chronic and Acute Venous Insufficiency Wounds 

3rd congress of the World Union of Wound Healing Societies, June 4-8, 2008, Toronto, Canada  

Lee J.H. et al.  (2008): 

The efficacy of topical 0.2% hyaluronic acid gel on recurrent oral ulcers: comparison between recurrent aphthous ulcers and the oral ulcers of Behçet's disease

J Eur Acad Dermatol Venereol. 2008 May;22(5):590-5 

Meaume S. et al. (2008): 


Efficacy and tolerance of a hydrocolloid dressing containing hyaluronic acid for the treatment of leg ulcers of venous or mixed origin. 

Curr Med Res Opin 24(10):2729–2739

Nolan A. (2006):

The efficacy of topical hyaluronic acid in the management of recurrent aphthous ulceration 

J Oral Pathol Med. 2006 Sep;35(8):461-5

Costagliola M., Agrosì M. (2005): 

Second-degree burns: a comparative, multicenter, randomized trial of hyaluronic acid plus silver sulfadiazine vs. silver sulfadiazine alone
Curr Med Res Opin. 2005 Aug;21(8):1235-40 

Gravante J. (2004): 

Topical treatment of partial thickness burns by silver sulfadiazine plus hyaluronic acid compared to silver sulfadiazine alone: a double-blind, clinical study
Drugs Exp Clin Res. 2004;30(5-6):183-90  

Koller J. (2004): 

Topical treatment of partial thickness burns by silver sulfadiazine plus hyaluronic acid compared to silver sulfadiazine alone: a double-blind, clinical study
Drugs Exp Clin Res. 2004;30(5-6):183-90 

Taddeucci P. et al. (2004): 

An evaluation of Hyalofill-F plus compression bandaging in the treatment of chronic venous ulcers
J Wound Care. 2004 May;13(5):202-4 

Caravaggi C. et al. (2003): 

HYAFF 11-based autologous dermal and epidermal grafts in the treatment of noninfected diabetic plantar and dorsal foot ulcers: a prospective, multicenter, controlled, randomized clinical trial
Diabetes Care. 2003 Oct;26(10):2853-9 

Colletta V. et al. (2003):


A trial to assess the efficacy and tolerability of Hyalofill-F in non-healing venous leg ulcers
J Wound Care. 2003 Oct;12(9):357-60  

Ortonne J.P. (2001): 

Comparative study of the activity of hyaluronic acid and dextranomer in the treatment of leg ulcers of venous origin
Ann Dermatol Venereol. 2001 Mar;Suppl:13-6 

Tankova T. et. al. (2001):

Zinc hyaluronate in the treatment of diabetic foot ulcers: A controlled randomized open-label study
Diabetologia Croatica 2001; 30(3):93-96 

Foster A.M. et al. (1999):

The treatment of indolent neuropathic ulceration of the diabetic foot with Hyaff, an ester of hyaluronic acid
Diabetologia 1999, 42(suppl 1):A29 

 Liguori V. et al. (1997):

Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy 
Radiother Oncol. 1997 Feb;42(2):155-61  

Ortonne J.P. (1996):

A controlled study of the activity of hyaluronic acid in the treatment of venous leg ulcers 
Journal of Dermatological Treatment, 1996; 7:75-81