Klinische Studien und Fallstudien Hyaluronsäure

Konrad S. et al. (2023): 

Die Wirksamkeit von Hyaluronsäure: Wundversorgung bei Druckgeschwüren
(Dekubitus)  In: Medizin & Praxis, Der sakrale Dekubitus, 01/2023, S. 29-35

Kamden A.F.  et al. (2021): 

Assessment of care protocol using hyaluronic acid dressing in Second-Degree skin burns in children.  Burns Open (2021) 118-124 

Kapitán M.  et al. (2021): 

Initial Observation of Factors Interfering with the Treatment of Alveolar Osteitis Using Hyaluronic Acid with Octenidine-A Series of Case Reports.
Biomolecules. 2021 Aug 4;11(8):1157 

Keese M., Born S. (2021): 

Efficacy of hyaluronic acid in diabetic foot ulcers - reactivation of stagnant wounds. (Wirkeffizienz von Hyaluronsäure bei diabetischen Fußulzera – Reaktivierung stagnierender Wunden)
Medizin & Praxis: In Focus - Wound Care in Geriatrics. 11/2021 p. 29-34

 Capodiferro S. et al. (2020):


Aminogam® Gel Allows Faster Wound Healing after Oral Surgery by Formation of Mature Connective Tissue with Low Vascular Density and Reducing Inflammatory Infiltration. A Retrospective Study on 580 Cases with Histological and Confocal Laser Investigation. Appl. Sci. 2020, 10(3), 1105  

 Cassuto D., Vinshtok Y. (2020):


Treatment of Scar Contracture with Intralesional Jet-Assisted Injection of Hyaluronic acid.  J Dermatol Res Ther 2020, 6:094 

Nair H. K. R. (2020):


Application of hyaluronic acid and collagenase ointment in the treatment of chronic wounds: a case series.  Wounds Asia 2020, Vol 3 Issue 2 

Velamuri S.R. et al. (2020):


107 Esterified Hyaluronic Acid Matrix in Lower Extremity Wound Reconstruction 
Journal of Burn Care & Research, Volume 41, Issue Suppl. 1, March 2020, p. S70–S71 

Visintin E., Ciancimi C. (2020): 

PRP and dermal substitute soaked in PRP for the treatment of acute and chronic wounds. EWMA 2020 Virtual Conference 18 – 19 November 2020, EP122

Aballay A., Hermans M.H.E. (2019): 

Neodermis Formation in Full Thickness Wounds Using an Esterified Hyaluronic Acid Matrix. J Burn Care Res. 2019 Aug 14;40(5):585-589 

 Caravaggi C. et al. (2019): 

Safety and efficacy of hyaluronan based bio-inductive dermal substitute in coverage of cancellous bone after surgical debridement for severe diabetic foot infection in reconstructive surgical approach: prospective, observational study 
EWMA 2019 Gothenburg, Sweden 5 - 7 June 2019, EP029

 Caravaggi C. et al. (2019): 

Value, safety, effectiveness and outcome of a new biological dressing based on collagen and hyaluronic acid in treatment of non-infected and non-ischemic dorsal and plantar diabetic foot ulcers: a prospective, non-controlled observational study
EWMA 2019 Gothenburg, Sweden 5 - 7 June 2019, EP028

 Cassino R., Hussein A.   (2019): 

A topical treatment (gel & cream) to achieve smooth and elastic scars in second and third degree burns. EWMA 2019 Gothenburg, Sweden 5 - 7 June 2019, EP089

Gazzabin L. et al. (2019): 

Hyaluronic acid and metallic silver treatment of chronic wounds: healing rate and bacterial load control. J Wound Care. 2019 Jul 2;28(7):482-490 

Gualdi G. et al. (2019):


Hyaluronic Acid-based Products are Strictly Contraindicated in Scleroderma-related Skin Ulcers. Wounds. 2019 Mar;31(3):81-84 

Pertea M. et al. (2019): 

Negative pressure therapy followed by use of hyaluronic acid plus silver sulfadiazine 

EWMA 2019 Gothenburg, Sweden 5 - 7 June 2019, EP062

Sobotka L. et al. (2019): 

The treatment of deep wounds and cavities with combined self-adherent hyaluronan octenidine wound dressing 

EWMA 2019 Gothenburg, Sweden 5 - 7 June 2019, EP625

Suchánek J. et al. (2019):

Hyaluronic Acid-Based Medical Device for Treatment of Alveolar Osteitis—Clinical Study. Int J Environ Res Public Health. 2019 Oct; 16(19): 3698  

 Cheung T. et al. (2018):

Outcomes of an Esterified Hyaluronic Acid Matrix in the Treatment of Chronic Lower Extremity Wounds: A Case Series. Wounds. 2018 Dec;30(12):367-371 

 Nicoletti G. et al. (2018):

Skin cancers and dermal substitutes: Is it safe? Review of the literature and presentation of a 2-stage surgical protocol for the treatment of non-melanoma skin cancers of the head in fragile patients. Indian J Plast Surg. 2018 Jan-Apr; 51(1): 46–53

Marcasciano M. et al. (2018):

Versatile use of dermal substitutes: A retrospective survey of 127 consecutive cases 

Int Wound J. 2018 Oct;15(5):756-768  

Simman R. (2018): 

The Role of an Esterified Hyaluronic Acid Matrix in Wound Healing, a Case Series
J Am Coll Clin Wound Spec. 2016; 8(1-3): 10–11 

Simman R. (2018): 

Use of Hyaluronic Acid-Based Biological Bilaminar Matrix in Wound Bed Preparation: A Case Series. Eplasty  2018 Apr 26;18:e17  

Sobotka L. et al. (2018): 

The treatment of large abdominal dehiscences with new combined self-adherent antimicrobial wound dressing.  EWMA 2018 Krakow, Poland 9 – 11 May 2018, EP198

Malutina N., Alekseev A.  (2017): 

Prevention of post-burn scarring using hyaluronidase preparations 

EWMA 2017Amsterdam The Netherlands 3-5 May 2017 EP326

Tagliagambe M. (2017): 

Hyaluronic Acid Sodium Salt 0.2% Gel in the Treatment of a Recalcitrant Distal Leg Ulcer. A Case Report. J Clin Aesthet Dermatol. 2017 Nov; 10(11): 49–51 

De Caridi G. et al. (2016): 

Trophic effects of polynucleotides and hyaluronic acid in the healing of venous ulcers of the lower limbs: a clinical study. Int Wound J. 2016 Oct;13(5):754-8  

Beniamino P. et al. (2016):


Cross-linked hyaluronic acid in pressure ulcer prevention 

J Wound Care. 2016 Jul 2;25(7):400-5  

Onesti M. G. et al. (2016):

Non-surgical treatment of deep wounds triggered by harmful physical and chemical agents: a successful combined use of collagenase and hyaluronic acid

Int Wound J. 2016 Feb;13(1):22-6  

Cassino R. et al. (2015):

Evaluation of the effectiveness of a hyperoxidized oil-based medication in the treatment of skin lesions: observational study. Minerva Chir. 2015 Feb;70(1):23-31  

Fino P. et al. (2015):

Caustic burn caused by intradermal self administration of muriatic acid for suicidal attempt: optimal wound healing and functional recovery with a non surgical treatment 

G Chir. Sep-Oct 2015;36(5):214-8   

Yu A. et al. (2015):

Preliminary Clinical Study Using a Novel Wound Dressing Composed of Hyaluronic Acid and Collagen Containing EGF.  Open Journal of Regenerative Medicine, 4, 6-13

Landi A. et al. (2014):

Hyaluronic acid scaffold for skin defects in congenital syndactyly release surgery: a novel technique based on the regenerative model

J Hand Surg Eur Vol. 2014 Nov;39(9):994-1000  

Marchesi A. et al.  (2014):

Allogeneic epidermal substitutes in the treatment of chronic diabetic leg and foot ulcers. Plast Aesthet Res 2014;1:74-80  

Onesti M.G.. et al.  (2014):

Long-term in vivo assessment of bioengineered skin substitutes: a clinical study 

Int Wound J. 2016 Apr;13(2):198-203   

Nicoletti G. et al.  (2014):

Reconstruction after skin cancer excision through a dermal induction template: our experience. J Tissue Eng Regen Med. 2015 Apr;9(4):460-8  

 Schlesinger T., Rowland Powell C. (2014):

Efficacy and safety of a low molecular weight hyaluronic Acid topical gel in the treatment of facial seborrheic dermatitis final report
J Clin Aesthet Dermatol. 2014 May;7(5):15-8 

Shoeib F. et al. (2014):

Use of hyaluronic acid-derived dermal substitute for skin reconstruction in giant omphalocele. Annals of Pediatric Surgery 2014, Vol 10 No 3 

Sobotka L. et al. (2014):

The combination of hyaluronate-iodine complex and negative pressure therapy on non-healing diabetic wounds. EWMA 2014, 14-16 May 2014, Madrid, Spain, P280 

Sobotka L. et al. (2014):

The combination of negative pressure and hyaluronate-iodine dressing in complicated abdominal wounds. EWMA 2014, 14-16 May 2014, Madrid, Spain, P351

Anniboletti T. et al. (2013): 

Our experience in the treatment of burn patients with hyaluronic acid and collagenases

EWMA, 2013, May 15-17, Copenhagen, Denmark, EP431 

Carella S. et al. (2013):


An atypical case of Henoch-Shonlein purpura in a young patient: treatment of the skin lesions with hyaluronic acid-based dressings. In Vivo. Jan-Feb 2013;27(1):147-51 

Campanati A. et al. (2013): 

Topical ozonated oil versus hyaluronic gel for the treatment of partial- to full-thickness second-degree burns: A prospective, comparative, single- blind, non-randomised, controlled clinical trial. Burns. 2013 Sep;39(6):1178-83 

Dessy L. A. et al. (2013):


Hyaluronic acid three-dimensional scaffold for surgical revision of retracting scars: a human experimental study. In Vivo. Jan-Feb 2013;27(1):153-8 

Faga A. et al. (2013): 

Hyaluronic acid three-dimensional scaffold for surgical revision of retracting scars: a human experimental study. Int Wound J. 2013 Jun;10(3):329-35 

Gravante G. et al. (2013):


Multicenter clinical trial on the performance and tolerability of the Hyaluronic acid-collagenase ointment for the treatment of chronic venous ulcers: a preliminary pilot study. Eur Rev Med Pharmacol Sci.. 2013 Oct;17(20):2721-7

Motolese A. et al. (2013): 

Interaction between a regenerative matrix and wound bed in nonhealing ulcers: results with 16 cases. Biomed Res Int. 2013;2013:849321 

Onesti M.G. et al.  (2013):


A new association between hyaluronic acid and collagenase in wound repair: an open study. Eur Rev Med Pharmacol Sci. 2013 Jan;17(2):210-6  

Vaienti L. et al.  (2013):

Limb trauma: the use of an advanced wound care device in the treatment of full-thickness wounds. Strategies Trauma Limb Reconstr. 2013 Aug; 8(2): 111–115  

Fioramonti P. et al.  (2012):


A Successful Collagenase and Hyaluronic Acid Topical Use Combined with Antibiotic Therapy in the Treatment of Ulcerative Lesions Arising on Tattoo
Case Rep Med. 2012; 2012:253492  

Juhász I. et al. (2012): 

Treatment of partial thickness burns with Zn-hyaluronan: lessons of a clinical pilot study. Ann Burns Fire Disasters. 2012 Jun 30;25(2):82-5. 

Parry-Ellis R. (2012): 

Activating healing naturally in three chronic ulcers using Hyaluronic Acid/Iodine Complex
Bwrdd Iechyd Prifysgol, Betsi Cadwaladr University Health Board, GIG, CYMRU, NHS, WALES, TVS 2012

Brenes R.A. et al. (2011): 

Initial experience using a hyaluronate-iodine complex for wound healing

Am Surg. 2011 Mar;77(3):355-9 

Brenes R.A. et al. (2011): 

Hyaluronate-iodine complex: a new adjunct for the management of complex sternal wounds after a cardiac operation. Arch Surg. 2011 Nov;146(11):1323-5

Cutting K. et al. (2011): 

Hyiodine in action. The journey continues. Suppl. The Diabetic Foot Journal 14:4, 2011

Ott K., Diener U. (2011): 

Alternative in der Behandlung chronischer sowie akut-infektiöser, therapieresistenter Wunden durch Hyaluronsäure kombiniert mit bakterizidem Wirkstoff (Hyaluronat-Iodine-Komplex). Schweizer Gesellschaft für Wundbehandlung (SAfW) & Austrian Wound Association (AWA) 

Perrot P. et al. (2011):

Hyalomatrix PA(®) in skin substitutes. About 10 cases
Ann Chir Plast Esthet. 2011 Apr;56(2):107-11

 Stanway S. et al. (2011):

Management of a chronic wound in an end of life patient using Hyiodine
Salford Royal Foundation Trust, NHS, University Teaching Hospital, UK, Wounds 2011

 Vindigni V. et al. (2011):

Temporary coverage of a forehead defect following tumor resection with a hyaluronic acid biological dressing: a case report
Ostomy/Wound Management, 01 Apr 2011, 57(4):56-60

Cassino R., Ricci E.  (2010):

Effectiveness of topical application of amino acids to chronic wounds: a prospective observational study. J Wound Care. 2010 Jan;19(1):29-34 

 Durante C.M. et al. (2010):

Influence of hyaluronate iodine gel on recalcitrant wounds
EWMA 2010 Geneva, Switzerland, 26 - 28 May, 2010, P97

Gravante G. et al. (2010):

Hyalomatrix PA in burn care practice: results from a national retrospective survey, 2005 to 2006. Ann Plast Surg. 2010 Jan;64(1):69-79

 Koo H.K. et al. (2010):

The Use of Hyalomatrix(R) in the Treatment of Difficult To Heal Wound
J Korean Soc Plast Reconstr Surg. 2010 Sep;37(5):600-606 

 Wild T. et al. (2010):

New galenic antiseptic substance containing iodine (KI3 complex) and hyaluronic acid for treatment of chronic, hardly healing wounds
Journal of Wound Technology, No 7, Jan 2010, 63-65 

 Wild T. et al. (2010):

New galenic antiseptic substance containing iodine complex and hyaluronic acid (hyiodine) for treatment of chronic, hardly healing wounds
EWMA 2010, May 26-28, Geneva, Switzerland, P155  

Paghetti A. et al. (2009): 

Topic efficacy of ialuronic acid associated with argentic sulphadiazine (Connettivina Plus) in the treatment of pressure sores: a prospective observational cohort study
Prof Inferm. 2009 Apr-Jun;62(2):67-77 

Brennes R. A. et al. (2008): 

Cumulative Initial Experience Using Hyaluronate-Iodine Complex (Hyiodine) in Wound Healing. New England Surgical Society 89th, Annual Meeting, Boston, USA, September 2008 

Cap R. et al. (2008): 

Effect of hyaluronate-iodine-complex (Hyiodine) in skin grafting of chronic infected wounds. EWMA 2008, May 14–16, 2008, Lissabon, Portugal, P175 

Plodr M. et al. (2008): 

Complex of Hyaluronic acid and iodine (Hyiodine) in war soft tissue injuries – first experience (case reports). EWMA 2008, May 14–16, 2008, Lissabon, Portugal, P185 

 Scuderi N. et al. (2008):

The clinical application of autologous bioengineered skin based on a hyaluronic acid scaffold. Biomaterials. 2008 Apr;29(11):1620-9  

Sobotka L. et al. (2008): 

New method for healing of large abdominal wound using sodium-hyaluronate-iodine complex. EWMA 2008, May 14–16, 2008, Lissabon, Portugal, P066

Sobotka L. et al. (2008): 

Successful treatment of surgical abdominal wounds complicated by multiple bowel fistulas with a combination of total parenteral nutrition, hyaluronan-iodine complex and delayed surgery: results of a monocentric experience 
Nutritional Therapy & Metabolism 2008; 26: 177-83 

Ajemian M. et al. (2007):


Hyaluronate-iodine (Hyiodine) complex in the treatment of non-healing wounds Journal of the American College of Surgeons. 205. S55  (Poster)   PDF

Barrois B. et al. (2007):


Efficacy and tolerability of hyaluronan (ialuset) in the treatment of pressure ulcers: a multicentre, non-randomised, pilot study. Drugs R D. 2007;8(5):267-73  

Esposito G. et al. (2007): 

Use of hyaluronan dressings following dermabrasion avoids escharectomy and facilitates healing in pediatric burn patients.
Plast Reconstr Surg 2007; 19(7):2346–2347  

Gravante G. et al. (2007):


The use of Hyalomatrix PA in the treatment of deep partial-thickness burns   
J Burn Care Res. 2007 Mar-Apr;28(2):269-74 

Sobotka L. et al. (2007): 

A case report of the treatment of diabetic foot ulcers using a sodium hyaluronate and iodine complex. Int J Low Extrem Wounds. 2007 Sep;6(3):143-7. 

Sobotka L. et al. (2007): 

Use of hyaluronate iodine complex for the treatment of hepatic abscess cavities
A.S.P.E.N, clinical nutrition week, Phoenix, USA, January 28-31, 2007

Sobotka L. et al. (2006): 

Complex approach to the treatment of diabetic foot defects
EWMA 2006, May 18 – 20, Prague, Czech Republic  

Sobotka L. et al. (2006): 

Sodium hyaluronate and an iodine complex--Hyiodine--new method of diabetic defects treatment. Vnitr Lek. 2006 May;52(5):417-22 

Vaiude P. et al. (2006):


Hyalomatrix® – A novel dermal pre-treatment. JPRAS 2007. 60:4, PS14

Voinchet V. et al. (2006): 

Efficacy and safety of hyaluronic acid in the management of acute wounds.
Am J Clin Dermatol. 2006;7(6):353-7. 

Ballard K., Cantor A. J. (2003):


Treating Recalcitrant Diabetic Wounds with Hyaluronic Acid: A Review of Patients
Ostomy Wound Manage. 2003; 49(4):37-49

Colletta V. et al. (2003):


A trial to assess the efficacy and tolerability of Hyalofill-F in non-healing venous leg ulcers. J Wound Care. 2003 Oct;12(9):357-60

Lobmann R. et al. (2003):


Autologous human keratinocytes cultured on membranes composed of benzyl ester of hyaluronic acid for grafting in nonhealing diabetic foot lesions: a pilot study
J Diabetes Complications. Jul-Aug 2003;17(4):199-204 

Uccioli L. (2003):


Autologous human keratinocytes cultured on membranes composed of benzyl ester of hyaluronic acid for grafting in nonhealing diabetic foot lesions: a pilot study
Wounds: A Compendium of Clinical Research and Practice 15(9):279-288 

Vazquez J.R. et al. (2003): 

Outcomes of hyaluronan therapy in diabetic foot wounds
Diabetes Res Clin Pract. 2003 Feb;59(2):123-7

Meaume S. (2001): 

Role of dressings with hyaluronic acid base in the treatment of leg ulcers
Ann Dermatol Venereol. 2001 Mar;Suppl:17-20 

Hollander D. et al. (2000):


Using an esterified hyaluronan fleece to promote healing in difficult-to-treat wounds
J Wound Care. 2000 Nov;9(10):463-6